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dc.contributor.authorChiamaka, Ezeh Anthoniade
dc.contributor.authorUchechukwu, Egbe Justinede
dc.contributor.authorChioma, Dike Sandrade
dc.contributor.authorAsonye, Ruthde
dc.contributor.authorChijioke, Onuh Kennethde
dc.contributor.authorChiemela, Divine Chidinmade
dc.date.accessioned2024-02-06T13:15:23Z
dc.date.available2024-02-06T13:15:23Z
dc.date.issued2023de
dc.identifier.issn2413-9009de
dc.identifier.urihttps://www.ssoar.info/ssoar/handle/document/91947
dc.description.abstractOne of the significant side effects of doxorubicin treatment for cancer patients is cognitive impairment, and the mechanisms underlying this impairment must be investigated to treat or prevent it. The current study investigates the impact of virgin coconut oil and carvedilol administration on neurobehaviour brain apoptotic and inflammatory markers in doxorubicin-treated mice. 32 male and 32 female mice were randomly assigned to four groups of 8 animals each, and the treatment lasted for twenty-eight days. Group 1 animals in both the male and female groups were the controls. In comparison, the Group 2 animals in both groups received doxorubicin dosage (3.75mg/kg body weight) intraperitoneally weekly as a single dose on days 5, 12, 19 and 26 to make up for the desired amount (15 mg/kg body weight). Group 3 animals received doxorubicin and were orally treated with virgin coconut oil (5ml/kg body weight) for 28 days. Group 4 animals received doxorubicin and were treated with carvedilol (5 mg/kg body weight) weekly for three days (days 5-7 for four weeks). The histological analysis of the brain tissue was done by staining the tissues with haematoxylin and eosin. The data was analyzed using GraphPad Prism 9.0. Analysis of Variance (ANOVA) was used to compare between groups. All results were presented as mean±SEM. Both virgin coconut oil and carvedilol demonstrated ameliorative effects on neurobehaviour and apoptotic and inflammatory brain markers.de
dc.languageende
dc.subject.ddcMedizin und Gesundheitde
dc.subject.ddcMedicine and healthen
dc.titleImpact of Virgin Coconut Oil and Carvedilol on Neurobehaviour, Apoptotic and Inflammatory Brain Markers in Doxorubicin Treated Micede
dc.description.reviewbegutachtet (peer reviewed)de
dc.description.reviewpeer revieweden
dc.source.journalPath of Science
dc.source.volume9de
dc.publisher.countryMISCde
dc.source.issue9de
dc.subject.classozMedizin, Sozialmedizinde
dc.subject.classozMedicine, Social Medicineen
dc.rights.licenceCreative Commons - Namensnennung 4.0de
dc.rights.licenceCreative Commons - Attribution 4.0en
internal.statusformal und inhaltlich fertig erschlossende
dc.type.stockarticlede
dc.type.documentZeitschriftenartikelde
dc.type.documentjournal articleen
dc.source.pageinfo4020-4049de
internal.identifier.classoz50100
internal.identifier.journal1570
internal.identifier.document32
internal.identifier.ddc610
dc.identifier.doihttps://doi.org/10.22178/pos.96-6de
dc.description.pubstatusVeröffentlichungsversionde
dc.description.pubstatusPublished Versionen
internal.identifier.licence16
internal.identifier.pubstatus1
internal.identifier.review1
internal.dda.referencehttps://pathofscience.org/index.php/index/oai/@@oai:ojs.pathofscience.org:article/2920
ssoar.urn.registrationfalsede


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