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Associations of neural error-processing with symptoms and traits in a dimensional sample recruited across the obsessive-compulsive spectrum
[journal article]
Abstract The error-related negativity (ERN), a neural response to errors, has been associated with several forms of psychopathology and assumed to represent a neural risk marker for obsessive–compulsive disorder (OCD) and anxiety disorders. Yet, it is still unknown which specific symptoms or traits best expl... view more
The error-related negativity (ERN), a neural response to errors, has been associated with several forms of psychopathology and assumed to represent a neural risk marker for obsessive–compulsive disorder (OCD) and anxiety disorders. Yet, it is still unknown which specific symptoms or traits best explain ERN variation. This study investigated performance-monitoring in participants (N = 100) recruited across a spectrum of obsessive-compulsive characteristics (n = 26 patients with OCD; n = 74 healthy participants including n = 24 with low, n = 24 with medium, and n = 26 with high OC-characteristics). Several compulsivity- and anxiety-associated characteristics were assessed and submitted to exploratory principal axis factor analysis. Associations of raw measures and derived factors with ERN and correct-related negativity (CRN) were examined. Patients with OCD showed increased ERN amplitudes compared to healthy participants. The ERN was associated with a variety of traits related to anxiety and negative affect. Factor analysis results revealed a most prominent association of the ERN with a composite measure of anxiety and neuroticism, whereas the CRN was specifically associated with compulsivity. Results support differential associations for the ERN and CRN and demonstrate that a dimensional recruitment approach and use of composite measures can improve our understanding of characteristics underlying variation in neural performance monitoring.... view less
Keywords
anxiety; compulsion; error; neuropsychology; psychopathology
Classification
Psychological Disorders, Mental Health Treatment and Prevention
Free Keywords
error-related negativity ERN; event-related potentials ERP; obsessive-compulsive disorder; transdiagnostic symptoms; ZIS 242; ZIS 219
Document language
English
Publication Year
2023
Page/Pages
p. 1-16
Journal
Psychophysiology, 60 (2023) 2
DOI
https://doi.org/10.1111/psyp.14164
ISSN
1469-8986
Status
Published Version; peer reviewed